Products for Research Use Only
RegisterLogin

CD11a Antibody / LFA-1

CAT: 0800-R32698Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-R32698Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CD11a, also known as ITGAL or LFA-1, is a human gene which functions in the immune system. It is mapped to 16p11.2. CD11a is involved in cellular adhesion and costimulatory signaling. It is the target of the drug efalizumab. CD11a encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. It is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow Cytometry:1-2 µg/mL, Immunocytochemistry: 1-2 µg/mL
UniProt
P20701
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids F161-L349 from the human protein were used as the immunogen for the CD11a antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Reconstitution
After reconstitution, the CD11a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CD11a antibody is available for research use only.
Storage Conditions
After reconstitution, the CD11a antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CD11a antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) Jurkat and 2) CCRF-CEM cell lysate with CD11a antibody at 0.5ug/ml. Predicted molecular weight: ~129 kDa (unmodified), up to 200 kDa (glycosylated) .

UniProtKB · P20701

Integrin alpha-L

ITAL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20701
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGAL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O43746, Q45H73, Q96HB1, Q9UBC8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesionHost-virus interactionPhagocytosis

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
R36394-100UGLFA-1 Antibody / CD11a
R34026-100UGLFA-1 Antibody / CD18
R31562LFA-1 Antibody / CD18 / ITGB2
RQ5103ITGB2 Antibody / CD18 / LFA-1
RQ5156CD2 Antibody / LFA-2
V4656-20UGRecombinant LFA-2 Antibody / CD2
V4656-100UGRecombinant LFA-2 Antibody / CD2
V4656SAF-100UGRecombinant LFA-2 Antibody / CD2
V4045SAF-100UGLymphocyte Function Antigen 2 Antibody / LFA-2 / CD2
V4061SAF-100UGCD2 Antibody / Lymphocyte Function Antigen 2 / LFA-2

Alternative Products

CatalogName
GTR18571975CD11a Antibody / LFA-1
GTR18578356CD11a/LFA-1α Antibody
GTR18578353-01LFA-1α/CD11a Antibody
STJ16100085Anti-CD11a/LFA-1 antibody
GTR18578366-01Mouse CD11a/LFA-1α Antibody
PT_74706-01CD11a (LFA-1), Rat Anti-Mouse (CD11a Antibody)
GWB-3F16B0CD11a/LFA-1a, Antibody
T9901A-165-01Anti-CD11a/LFA-1α Antibody (R7-1)
GWB-6038E7CD11a/LFA-1a Mouse, Antibody
GWB-994473CD11a/LFA-1a -PE, Antibody

Popular Products