TRPC6 Antibody

CAT: 0800-V4150-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V4150-20UGSize:20 µg
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Description
Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate, and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, LDOPA, which is used as a common therapy for Parkinson s disease (PD) patients, inhibits TPH function which, subsequently, is thought to contribute to the onset of depression in PD patients.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q9Y210
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human TRPC6 protein was used as the immunogen for the TRPC6 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
TRPC6/7672
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TRPC6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TRPC6 antibody is available for research use only.
Storage Conditions
Aliquot the TRPC6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TRPC6 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC staining of FFPE human pancreas tissue with TRPC6 antibody (clone TRPC6/7672) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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