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NSC-658497

CAT: 0804-HY-19539-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19539-01Size:10 mg
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Description
NSC-658497 is an effective inhibitor of Ras-GEF, SOS1. NSC-658497 binds to SOS1, competitively suppresses SOS1-Ras interaction, and dose-dependently inhibits SOS1 GEF activity. NSC-658497 showed dose-dependent efficacy in inhibiting Ras, downstream signaling activities, and associated cell proliferation[1].
CAS Number
909197-38-2
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-658497.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(C(C2=CC=CC=C2O1)=O)=C\N3C(S/C(C3=O)=C\C4=CC=C([N+]([O-])=O)C=C4)=S
Molecular Formula
C20H10N2O6S2
Molecular Weight
438.43
References & Citations
[1]Evelyn CR, et al. Rational design of small molecule inhibitors targeting the Ras GEF, SOS1. Chem Biol. 2014;21 (12) :1618-1628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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