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NSC 625987

CAT: 0804-HY-103380-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103380-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 625987 is a specific and high-affinity CDK4 inhibitor with an IC50 of 0.2 μM for CDK4:cyclin D1. NSC 625987 shows >500-fold selectivity for CDK4 over CDK2[1].
CAS Number
141992-47-4
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-625987.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C1C2=C(C=CC=C2)NC3=C(OC)C=CC(OC)=C13
Molecular Formula
C15H13NO2S
Molecular Weight
271.33
References & Citations
[1]A Kubo, et al. The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4. Clin Cancer Res. 1999 Dec;5 (12) :4279-86.|[2]Jasmine El Andalousi, et al.Natriuretic peptide receptor-C agonist attenuates the expression of cell cycle proteins and proliferation of vascular smooth muscle cells from spontaneously hypertensive rats: role of Gi proteins and MAPkinase/PI3kinase signaling. PLoS One. 2013 Oct 14;8 (10) :e76183.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4

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