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HEPPS

CAT: 0804-HY-D0873-02Size: 50 gDry Ice: NoHazardous: No
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CAT#:0804-HY-D0873-02Size:50 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].
CAS Number
16052-06-5
Product Name Alternative
EPPS
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β
Type
Biochemical Assay Reagents
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hepps.html
Purity
99.04
Solubility
H2O : 233.33 mg/mL (ultrasonic)
Smiles
O=S(CCCN1CCN(CCO)CC1)(O)=O
Molecular Formula
C9H20N2O4S
Molecular Weight
252.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Chemical Information

Hepps

HEPPS is a N-(2-hydroxyethyl)piperazine and a N-(sulfoalkyl)piperazine.

CAS Number16052-06-5
PubChem CID85255
IUPAC Name3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Molecular FormulaC9H20N2O4S
Molecular Weight252.33
XLogP-3.6
Topological Polar Surface Area89.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count16
Formal Charge0
Complexity280
SMILES
C1CN(CCN1CCCS(=O)(=O)O)CCO
InChI
InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
InChIKey
OWXMKDGYPWMGEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Hepps
CAS: 16052-06-5
CID: 85255
Formula: C9H20N2O4S
MW: 252.33
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight252.33
XLogP3-3.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass252.11437830
Monoisotopic Mass252.11437830
Topological Polar Surface Area89.5 Ų
Heavy Atom Count16
Formal Charge0
Complexity280
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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FH15209-01HEPPS
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40520015-2HEPPS Buffer 0.2M, pH 8.0
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