HEPPS

• Description :

  HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

• CAS Number :

  [16052-06-5]

• Product Name Alternative :

  EPPS

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Amyloid-β

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/hepps.html

• Purity :

  99.04

• Solubility :

  H2O : 233.33 mg/mL (ultrasonic)

• Smiles :

  O=S(CCCN1CCN(CCO)CC1)(O)=O

• Molecular Formula :

  C9H20N2O4S

• Molecular Weight :

  252.33

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported