HEPPS

• Description:

  HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1].

• Product Name Alternative:

  EPPS

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Amyloid-β

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hepps.html

• Purity:

  99.04

• Solubility:

  H2O : 233.33 mg/mL (ultrasonic)

• Smiles:

  O=S(CCCN1CCN(CCO)CC1)(O)=O

• Molecular Formula:

  C9H20N2O4S

• Molecular Weight:

  252.33

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [16052-06-5]