Coenzyme Q0

• Description:

  Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].

• Product Name Alternative:

  CoQ0

• UNSPSC:

  12352200

• Hazard Statement:

  H315, H319, H335

• Target:

  Akt; Apoptosis; Autophagy; Bcl-2 Family; Caspase; COX; EGFR; Interleukin Related; MMP; mTOR; NF-κB; NO Synthase; PARP; Reactive Oxygen Species (ROS) ; TNF Receptor

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/coenzyme-q0.html

• Purity:

  99.79

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C(OC)=C(OC)C(C(C)=C1)=O

• Molecular Formula:

  C9H10O4

• Molecular Weight:

  182.18

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[2]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[3]Yang HL, et, al. Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells. Biochem Pharmacol. 2015 Nov 1;98 (1) :144-56.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [605-94-7]