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Coenzyme Q0

CAT: 0804-HY-W016412-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W016412-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling[1][2][3].
CAS Number
605-94-7
Product Name Alternative
CoQ0
UNSPSC
12352200
Hazard Statement
H315, H319, H335
Target
Akt; Apoptosis; Autophagy; Bcl-2 Family; Caspase; COX; EGFR; Interleukin Related; MMP; mTOR; NF-κB; NO Synthase; PARP; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Biochemical Assay Reagents
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/coenzyme-q0.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(OC)=C(OC)C(C(C)=C1)=O
Molecular Formula
C9H10O4
Molecular Weight
182.18
Precautions
H315, H319, H335
References & Citations
[1]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[2]Yang HL, et, al. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in vitro and in vivo studies. Biochim Biophys Acta. 2016 Feb;1859 (2) :246-61.|[3]Yang HL, et, al. Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells. Biochem Pharmacol. 2015 Nov 1;98 (1) :144-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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