Coenzyme A

• Description:

  Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite; Fatty Acid Synthase (FASN)

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/coenzyme-a.html

• Purity:

  97.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC ([C@H] (C (NCCC (NCCS) =O) =O) O) (C) COP (OP (OC[C@H]1O[C@@H] (N2C3=NC=NC (N) =C3N=C2) [C@H] (O) [C@@H]1OP (O) (O) =O) (O) =O) (O) =O

• Molecular Formula:

  C21H36N7O16P3S

• Molecular Weight:

  767.53

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44 (2-3) :125-5.|[2]Tsuchiya Y, et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells. Biochem J. 2018 Jun 6;475 (11) :1909-1937.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 4

• CAS Number:

  85-61-0