Coenzyme A

• Description :

  Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Endogenous Metabolite; Fatty Acid Synthase (FASN)

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/coenzyme-a.html

• Purity :

  97.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O)=O)(O)=O)(O)=O

• Molecular Formula :

  C21H36N7O16P3S

• Molecular Weight :

  767.53

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44 (2-3) :125-5.|[2]Tsuchiya Y, et al. Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells. Biochem J. 2018 Jun 6;475 (11) :1909-1937.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 4

• CAS Number :

  [85-61-0]