Ribociclib (Standard)

• Description:

  Ribociclib (Standard) is the analytical standard of Ribociclib. This product is intended for research and analytical applications. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

• Product Name Alternative:

  LEE011 (Standard)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  CDK; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Cell Cycle/DNA Damage; Others

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ribociclib-standard.html

• Purity:

  99.76

• Smiles:

  O=C (N (C) C) C (N1C2CCCC2) =CC (C1=N3) =CN=C3NC (N=C4) =CC=C4N5CCNCC5

• Molecular Formula:

  C23H30N8O

• Molecular Weight:

  434.54

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21 (13) :2905-10.|[2]Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19 (22) :6173-82.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• CAS Number:

  1211441-98-3