Ribociclib succinate (Standard)

• Description:

  Ribociclib succinate (Standard) is the analytical standard of Ribociclib succinate. This product is intended for research and analytical applications. Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.

• UNSPSC:

  12352100

• Target:

  CDK; Reference Standards

• Related Pathways:

  Cell Cycle/DNA Damage; Others

• Field of Research:

  Cancer

• Smiles:

  O=C (N (C) C) C (N1C2CCCC2) =CC (C1=N3) =CN=C3NC (N=C4) =CC=C4N5CCNCC5.OC (CCC (O) =O) =O

• Molecular Formula:

  C27H36N8O5

• Molecular Weight:

  552.63

• References & Citations:

  [1]VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21 (13) :2905-10.|[2]Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 15;19 (22) :6173-82.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1374639-75-4