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Ribociclib (hydrochloride) (Standard)

CAT: 0804-HY-15777AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15777AR-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ribociclib (Standard) (LEE011 (Standard) ) hydrochloride is the analytical standard of Ribociclib hydrochloride. This product is intended for research and analytical applications. Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex.
CAS Number
1211443-80-9
Product Name Alternative
LEE011 (hydrochloride) (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.96
Smiles
O=C(N(C)C)C1=CC2=C(N1C3CCCC3)N=C(NC4=NC=C(N5CCNCC5)C=C4)N=C2.Cl
Molecular Formula
C23H31ClN8O
Molecular Weight
471.00
Precautions
H302, H315, H319, H335
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed and dry storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported

Chemical Information

Ribociclib hydrochloride
CAS Number1211443-80-9
PubChem CID67242274
IUPAC Name7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide;hydrochloride
Molecular FormulaC23H31ClN8O
Molecular Weight471.0
Topological Polar Surface Area91.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity635
SMILES
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5.Cl
InChI
InChI=1S/C23H30N8O.ClH/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1H
InChIKey
JZRSIQPIKASMEV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ribociclib hydrochloride
CAS: 1211443-80-9
CID: 67242274
Formula: C23H31ClN8O
MW: 471.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass470.2309353
Monoisotopic Mass470.2309353
Topological Polar Surface Area91.2 Ų
Heavy Atom Count33
Formal Charge0
Complexity635
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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