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Reveromycin B

CAT: 0804-HY-125066Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125066Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively) . Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
CAS Number
144860-68-4
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/reveromycin-b.html
Smiles
CC(/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)=C\C[C@H]1O[C@]2(CC[C@@H]1C)CC[C@@](CCCC)(O2)[C@@H](OC(CCC(O)=O)=O)/C=C/C(C)=C/C(O)=O
Molecular Formula
C36H52O11
Molecular Weight
660.79
References & Citations
[1]Takahashi, et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J. Antibiot. (Tokyo) 45 (9), 1414-1419 (1992) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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