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Reveromycin A

CAT: 0804-HY-129337Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129337Size:1 mg
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Description
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity[1][2].
CAS Number
134615-37-5
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Fungal
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/reveromycin-a.html
Purity
99.00
Solubility
10 mM in DMSO
Smiles
O=C(O[C@@]1(CCCC)[C@H](/C=C/C(C)=C/C(O)=O)O[C@]2(O[C@H](C/C=C(C)/C=C/[C@H](O)[C@@H](C)/C=C/C(O)=O)[C@@H](C)CC2)CC1)CCC(O)=O
Molecular Formula
C36H52O11
Molecular Weight
660.79
References & Citations
[1]H Takahashi , et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J Antibiot (Tokyo) . 1992 Sep;45 (9) :1414-9.|[2]Je-Tae Woo, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103 (12) :4729-34.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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