PEN (human)

CAT: 0804-HY-P2278-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P2278-01Size:5 mg
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Description
PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].
CAS Number
[597578-70-6]
UNSPSC
12352209
Target
G protein-coupled Bile Acid Receptor 1
Type
Peptides
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pen-human.html
Purity
99.52
Solubility
H2O : 1.96 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@@H](N)C)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C97H159N27O32
Molecular Weight
2215.46
References & Citations
[1]Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10 (4) :1884-1891.|[2]Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9 (425) :ra43.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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