Products for Research Use Only
RegisterLogin

UK-500001

CAT: 0804-HY-119799Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119799Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
UK-500001 is an orally active inhibitor for phosphodiesterase 4 (PDE4), which inhibits PDE4D3 (IC50 is 0.28 nM), PDE4B2 (IC50 is 22.8 nM), PDE4A4 (IC50 is 26.1 nM) and PDE4C2 (IC50 is 271 nM) . UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-α and IFN-γ release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma[1].
CAS Number
582332-31-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/uk-500001.html
Smiles
O=C(C1=C(C=CC(C)=C1)O)N[C@H](CC2)CC[C@H]2NC(C(C=C(F)C=N3)=C3OC4=CC(F)=C(F)C=C4)=O
Molecular Formula
C26H24F3N3O4
Molecular Weight
499.48
References & Citations
[1]Moretto N, et al., CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352 (3) :559-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

Related Products

CatalogName
HY-111084UK 52831
HY-19391UK-240455
HY-101214-01UK-371804
HY-123150UK-447841
HY-108982UK 55444
HY-108200UK-315716
HY-105341UK 343664
HY-13102-01UK-383367
HY-123421UK-9040
HY-118148-01UK-66914

Alternative Products

CatalogName
TRC-U700630-250MGUk-500001
A4440-10UK 356618
A3899-10UK-5099
462157UK 370106
T69294-01UK-396082
T34990-01UK 39671
T29049-01UK-432097
T29050-01UK 66914
022640UK-356618
468442-01UK-1

Popular Products