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UK-66914

CAT: 0804-HY-118148-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118148-01Size:1 mg
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Description
UK-66914, is a class III antiarrhythmic agent that specifically acts on the delayed rectifier potassium current (I_K) . UK-66914 is designed to prolong action potential duration (APD) and increase cardiac refractory period, thereby potentially terminating the reentry mechanism in arrhythmias without affecting the serious side effects of antiarrhythmic drugs associated with other ion channels such as Na+ and Ca2+ currents[1].
CAS Number
113049-11-9
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/uk-66914.html
Smiles
CS(=O)(NC1=CC=C(C=C1)C(CN2CCN(CC2)C3=CC=NC=C3)O)=O
Molecular Formula
C18H24N4O3S
Molecular Weight
376.47
References & Citations
[1]Rees S A, et al. Pharmacology of a methanesulfonamide IK blocker, UK66, 914[J]. Cardiovascular drug reviews, 1992, 10 (2) : 158-169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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