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RA-9

CAT: 0804-HY-136528-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136528-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER) -stress responses in ovarian cancer cells[1].
CAS Number
[919091-63-7]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ra-9.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1/C(CNC/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
Molecular Formula
C19H15N3O5
Molecular Weight
365.34
Precautions
H302
References & Citations
[1]Coughlin K, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res. 2014;20 (12) :3174-3186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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