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AGN 205728

CAT: 0804-HY-16683-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16683-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 can inhibit abnormal proliferation of leukemia cells[1][2].
CAS Number
859498-05-8
UNSPSC
12352005
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AGN-205728.html
Purity
98.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C1)=CC=C1C2=CCC(C)(C)C3=C2C=CC(C(/C=C/C4=CC=C(C(O)=O)C=C4)=N/O)=C3
Molecular Formula
C29H27NO3
Molecular Weight
437.53
References & Citations
[1]Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.|[2]Watts JM, et al. A Case of AML Characterized by a Novel t (4;15) (q31; q22) Translocation That Confers a Growth-Stimulatory Response to Retinoid-Based Therapy. Int J Mol Sci. 2017 Jul 11;18 (7) :1492.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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AGN 205728 | 0804-HY-16683-01 | Gentaur