AGN 196996

• Description :

  AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM) . IC50 value: 2 nM (Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

• UNSPSC :

  12352005

• Target :

  Autophagy; RAR/RXR

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/AGN-196996.html

• Purity :

  99.76

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  BrC1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC(C(C3=CC=C(C)C=C3)=O)=C1OCC

• Molecular Formula :

  C24H20BrNO5

• Molecular Weight :

  482.32

• References & Citations :

  [1]Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85 (3) :453-62.|[2]Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91 (3) :580-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [958295-17-5]