PHGDH-IN-5

CAT: 0804-HY-161456-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-161456-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1].
CAS Number
[17402-86-7]
UNSPSC
12352005
Target
Phosphoglycerate Dehydrogenase (PHGDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phgdh-in-5.html
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S1(C2=CC=CC([N+]([O-])=O)=C2C=C1)=O
Molecular Formula
C8H5NO4S
Molecular Weight
211.19
References & Citations
[1]Cao XY, et al. Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors. Bioorg Chem. 2024;146:107330.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-179652PHGDH-IN-6
HY-145860PHGDH-IN-2
HY-121733-01PHGDH-inactive
HY-160252PHGDH-IN-4
HY-148570-01PHGDH-IN-3
HY-P87288-01PHGDH Antibody (YA6971, Mouse)
HY-P74633A-01PHGDH, Human (C-His)
HY-RS10432PHGDH Human Pre-designed siRNA Set A
HY-RS10433Phgdh Mouse Pre-designed siRNA Set A
HY-RS10434Phgdh Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
MF-0147716-01PHGDH-IN-5
328130-01PHGDH
bs-2970R-Cy5.5PHGDH Polyclonal Antibody, Cy5.5 Conjugated
MBS8605030-01PHGDH Antibody
DF12220-BPPHGDH Peptide
BUP08119-01PHGDH-IN-3
C4845-10PHGDH-inactive
MF-0147715-01PHGDH-IN-4
328131PHGDH discontinued

Popular Products