PHGDH-IN-5

• Target :

  Dehydrogenase

• Related Pathways :

  Metabolism

• Bioactivity :

  Compound B12 (PHGDH-IN-5) acts as a covalent inhibitor of PHGDH, demonstrating an IC50 value of 0.29 ?M. It has been shown to inhibit the proliferation of cancer cell lines that overexpress PHGDH and reduce the production of glucose-derived serine in MDA-MB-468 cells [1].

• Smiles :

  N(=O)(=O)C1=C2C(S(=O)(=O)C=C2)=CC=C1

• Molecular Formula :

  C8H5NO4S

• Molecular Weight :

  211.2

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  17402-86-7