PHGDH-IN-2

• Description :

  PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 μM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Phosphoglycerate Dehydrogenase (PHGDH)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/phgdh-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN1C(C(NC2=CC=CC(NS(=O)(C3=CC=C(C=C3)N)=O)=C2)=O)=CC4=C1C=CC=C4

• Molecular Formula :

  C22H20N4O3S

• Molecular Weight :

  420.48

• References & Citations :

  [1]Zhang FM, et al. Discovery of PHGDH inhibitors by virtual screening and preliminary structure-activity relationship study. Bioorg Chem. 2022, 121:105705.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported