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Estromustine

CAT: 0804-HY-126464Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126464Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Estromustine (EoM) is the active metabolite of Estramustine phosphate. Estromustine binds to mutant androgen receptor (m-AR) with EC50 of 2.6 μM in LNCaP, exhibits cytotoxicity in human prostate cells LNCaP with IC50 of 9.73 μM[1].
CAS Number
62899-40-5
Product Name Alternative
EoM
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/estromustine.html
Smiles
C[C@@]12[C@](CCC2=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3
Molecular Formula
C23H29Cl2NO3
Molecular Weight
438.39
Precautions
P261-P280-P302+P352
References & Citations
[1]Wang LG, et al., Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol. 1998 May 1;55 (9) :1427-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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