MAVS Rabbit Polyclonal Antibody

Required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

9007-83-4

CARD adapter inducing interferon beta antibody CARD adaptor inducing IFN beta antibody Cardif antibody DKFZp666M015 antibody FLJ27482 antibody FLJ41962 antibody IFN B promoter stimulator 1 antibody Interferon beta promoter stimulator protein 1 antibody Ips 1 antibody IPS-1 antibody Ips1 antibody KIAA1271 antibody MAVS antibody MAVS_HUMAN antibody Mitochondrial anti viral signaling protein antibody Mitochondrial Antiviral Signaling antibody Mitochondrial antiviral signaling protein antibody Mitochondrial antiviral-signaling protein antibody Putative NF kappa B activating protein 031N antibody Putative NF-kappa-B-activating protein 031N antibody Virus induced signaling adapter antibody virus induced signaling adaptor antibody Virus-induced-signaling adapter antibody VISA antibody

Mitochondrial antiviral-signaling protein MAVS CARD adapter inducing interferon beta (Cardif) Interferon beta promoter stimulator protein 1 (IPS-1) Putative NF-kappa-B-activating protein 031N Virus-induced-signaling adapter (VISA) MAVS IPS1 KIAA1271 VISA

Q7Z434 Human

Membrane, Mitochondrion, Mitochondrion outer membrane, Peroxisome.

Synthetic peptide within human MAVS aa 1-540 / 540.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P, FC

A549 cell lysate, MCF7 cell lysate, Jurkat cell lysate, HeLa cell lysate, A431 cell lysate, THP-1 cell lysate, HCT 116 cell lysate, HepG2 cell lysate, A431, human pancreas tissue.

1 mg/mL

WB: 1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:1,000 ;FC: 1:1,000

Protein A affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 56 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.