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(S) -Azelastine (hydrochloride)

CAT: 0804-HY-B0462BSize: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0462BSize:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Azelastine hydrochloride, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. (S) -Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
CAS Number
153408-27-6
Product Name Alternative
(+) -Azelastine (hydrochloride)
UNSPSC
12352005
Target
Histamine Receptor; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-azelastine-hydrochloride.html
Smiles
O=C1N([C@@H]2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4.Cl
Molecular Formula
C22H25Cl2N3O
Molecular Weight
418.36
References & Citations
[1]Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1 (2) :191-201.|[2]Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8.|[3]Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7 (6) : e00531.|[4]Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7.|[5]Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274 (2) :845-853.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

Chemical Information

(S)-Azelastine Hydrochloride
CAS Number153408-27-6
PubChem CID66586339
IUPAC Name4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1-one;hydrochloride
Molecular FormulaC22H25Cl2N3O
Molecular Weight418.4
Topological Polar Surface Area35.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity558
SMILES
CN1CCC[C@@H](CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl
InChI
InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H/t18-;/m0./s1
InChIKey
YEJAJYAHJQIWNU-FERBBOLQSA-N
Chemical Structure
2D Structure
2D structure of (S)-Azelastine Hydrochloride
CAS: 153408-27-6
CID: 66586339
Formula: C22H25Cl2N3O
MW: 418.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass417.1374678
Monoisotopic Mass417.1374678
Topological Polar Surface Area35.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity558
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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