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Leptin (116-130)

CAT: 0804-HY-P3340Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3340Size:1 Each
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Description
Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD) [1].
CAS Number
189224-35-9
UNSPSC
12352209
Target
IGluR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/leptin-116-130.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CS)NC([C@@H](N)CO)=O)=O)=O)=O)N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C64H108N18O25S
Molecular Weight
1561.72
References & Citations
[1] Malekizadeh Y, et al. A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin. Cereb Cortex. 2017;27 (10) :4769-4782.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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