Sortilin / NT3 Recombinant Rabbit Monoclonal Antibody [PSH06-16]

Sortilin / NT3 Recombinant Rabbit Monoclonal Antibody [PSH06-16]

• Description: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.
• Product Name Alternative: 100 kDa NT receptor antibody Glycoprotein 95 antibody Gp 95 antibody Gp95 antibody LDLCQ6 antibody Neurotensin receptor 3 antibody NT 3 antibody NT3 antibody NTR 3 antibody NTR3 antibody OTTHUMP00000013784 antibody SORT 1 antibody SORT_HUMAN antibody SORT1 (gene name) antibody Sort1 antibody Sortilin 1 antibody Sortilin antibody
• Abbreviation: Sortilin 100 kDa NT receptor Glycoprotein 95 (Gp95) Neurotensin receptor 3 (NT3; NTR3) SORT1
• CAS Number: 9000-83-3
• Swiss Prot: Q99523 Human, Q6PHU5 Mouse, O54861 Rat
• Cellular Locus: Cell membrane. Endoplasmic reticulum. Endosome. Golgi apparatus. Lysosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human Sortilin aa 78-755 (Extracellular).
• Isotype: IgG
• Clone: PSH06-16
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: SW480 cell lysate, HeLa cell lysate, 293T cell lysate, HepG2 cell lysate, SK-Br-3 cell lysate, U-2 OS cell lysate, U-87 MG cell lysate, Neuro-2a cell lysate, C6 cell lysate, Mouse brain tissue lysate, Mouse lung tissue lysate, Rat brain tissue lysate, Rat lung tissue lysate, human testis tissue, human brain tissue, mouse brain tissue, rat brain tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 92 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes