HPK1-IN-3

HPK1-IN-3

• CAS Number: 2739844-34-7
• UNSPSC Description: HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)[1].
• Target Antigen: MAP4K
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/hpk1-in-3.html
• Smiles: COC1=C(NC2=NC=C(C(N)=O)C(NC3=C(F)C=CC=C3C(F)(F)F)=N2)C=C4CN(C)CCC4=C1
• Molecular Weight: 490.45
• References & Citations: [1]Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.
• Shipping Conditions: Room Temperature