MG-C-30

CAT: 0804-HY-159886-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-159886-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MG-C-30 is an orally active agonist for CD27 with an EC50 of 0.84 μM. MG-C-30 activates NK cells and T cell co-stimulatory signals, and enhances immune response. MG-C-30 exhibits antitumor efficacy in mouse EG7-OVA model[1].

CAS Number

877164-43-7

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mg-c-30.html

Purity

95.55

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(OC)C=C(C2=NC(CC(NC(C3=NC4=C(C=CC=C4)N3)C(C)C)=O)=CS2)C=C1

Molecular Formula

C24H26N4O3S

Molecular Weight

450.55

References & Citations

[1]Abdel-Rahman SA, et al., Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints. Sci Adv. 2024 Oct 18;10 (42) :eadq5540.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TNFRSF7/CD27

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