β-Lapachone
CAT:
804-HY-13555-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
β-Lapachone
- CAS Number: 4707-32-8
- UNSPSC Description: β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
- Target Antigen: Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO); Topoisomerase
- Type: Natural Products
- Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/_beta_-Lapachone.html
- Smiles: O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O
- Molecular Weight: 242.27
- References & Citations: [1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268(30):22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401(1-2):55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31.
- Shipping Conditions: Room Temperature