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β-Lapachone

CAT: 0804-HY-13555-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13555-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Lapachone (ARQ-501; NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
CAS Number
[4707-32-8]
Product Name Alternative
ARQ-501; NSC-26326
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO) ; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_beta_-Lapachone.html
Purity
99.96
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : 8.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O
Molecular Formula
C15H14O3
Molecular Weight
242.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268 (30) :22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly (ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401 (1-2) :55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68 (1) :27-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
Topo I

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