β-Lapachone

• UNSPSC Description:

  β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

• Target Antigen:

  Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO); Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_beta_-Lapachone.html

• Smiles:

  O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O

• Molecular Weight:

  242.27

• References & Citations:

  [1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268(30):22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly(ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401(1-2):55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68(1):27-31.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  4707-32-8