β-Lapachone

• Description :

  β-Lapachone (ARQ-501; NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

• Product Name Alternative :

  ARQ-501; NSC-26326

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO) ; Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_beta_-Lapachone.html

• Purity :

  99.96

• Solubility :

  DMSO : 25 mg/mL (ultrasonic) |Ethanol : 8.33 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O

• Molecular Formula :

  C15H14O3

• Molecular Weight :

  242.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268 (30) :22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly (ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401 (1-2) :55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68 (1) :27-31.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 2

• Isoform :

  Topo I

• CAS Number :

  [4707-32-8]