β-Lapachone

• Description:

  β-Lapachone (ARQ-501; NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

• Product Name Alternative:

  ARQ-501; NSC-26326

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO) ; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_beta_-Lapachone.html

• Purity:

  99.96

• Solubility:

  DMSO : 25 mg/mL (ultrasonic) |Ethanol : 8.33 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C2OC (C) (C) CC1) C (C3=C2C=CC=C3) =O

• Molecular Formula:

  C15H14O3

• Molecular Weight:

  242.27

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268 (30) :22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly (ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401 (1-2) :55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68 (1) :27-31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 2

• Isoform:

  Topo I

• CAS Number:

  4707-32-8