β-Lapachone

CAT: 0026-2262-25Size: 25 mgDry Ice: NoHazardous: No
2262-2525 mg
Selected
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin (Cat. No. 1039), β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM).
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
24 months

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