Brinzolamide

Brinzolamide

• CAS Number: 138890-62-7
• UNSPSC Description: Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research[1][2].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Neurological Disease; Others; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Brinzolamide.html
• Purity: 99.61
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
• Molecular Weight: 383.51
• References & Citations: [1] Vatsala Naageshwaran, et al. Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration. J Pharm Sci. 2021 Jan;110(1):529-535.|[2] Sara M.Smith, et al. Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits,Journal of Drug Delivery Science and Technology,Volume 61,2021,102123,ISSN 1773-2247
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: Launched