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Brinzolamide (Standard)

CAT: 0804-HY-B0588R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0588R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brinzolamide (Standard) is the analytical standard of Brinzolamide. This product is intended for research and analytical applications. Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research[1][2].
CAS Number
138890-62-7
Product Name Alternative
AL-4862 (Standard)
UNSPSC
12352005
Target
Carbonic Anhydrase; Reference Standards
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/brinzolamide-standard.html
Smiles
O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
Molecular Formula
C12H21N3O5S3
Molecular Weight
383.51
References & Citations
[1] Vatsala Naageshwaran, et al. Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration. J Pharm Sci. 2021 Jan;110 (1) :529-535.|[2] Sara M.Smith, et al. Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits, Journal of Drug Delivery Science and Technology, Volume 61,2021,102123, ISSN 1773-2247
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Brinzolamide

Brinzolamide is a sulfonamide and a thienothiazine. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antiglaucoma drug.

CAS Number138890-62-7
PubChem CID68844
IUPAC Name(4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
Molecular FormulaC12H21N3O5S3
Molecular Weight383.5
XLogP-0.3
Topological Polar Surface Area164
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count23
Formal Charge0
Complexity598
SMILES
CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
InChI
InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
InChIKey
HCRKCZRJWPKOAR-JTQLQIEISA-N
Chemical Structure
2D Structure
2D structure of Brinzolamide
CAS: 138890-62-7
CID: 68844
Formula: C12H21N3O5S3
MW: 383.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.5
XLogP3-0.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass383.06433430
Monoisotopic Mass383.06433430
Topological Polar Surface Area164 Ų
Heavy Atom Count23
Formal Charge0
Complexity598
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
263603-01Brinzolamide

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