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Brinzolamide

CAT: 0804-HY-B0588-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0588-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brinzolamide (AL-4862) is a selective carbonic anhydrase II inhibitor with anIC50 value of 3.2 nM. Brinzolamide hydrochloride reduces intraocular pressure (IOP) by inhibiting ciliary CA-II and decreasing atrial fluid secretion. Brinzolamide can be used in glaucoma disease research[1][2].
CAS Number
138890-62-7
Product Name Alternative
AL-4862
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease; Others; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Brinzolamide.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C(S1)=CC2=C1S(N(CCCOC)C[C@@H]2NCC)(=O)=O)(N)=O
Molecular Formula
C12H21N3O5S3
Molecular Weight
383.51
Precautions
H302, H315, H319, H335
References & Citations
[1] Vatsala Naageshwaran, et al. Comprehensive Ocular and Systemic Pharmacokinetics of Brinzolamide in Rabbits After Intracameral, Topical, and Intravenous Administration. J Pharm Sci. 2021 Jan;110 (1) :529-535.|[2] Sara M.Smith, et al. Tolerability, pharmacokinetics, and pharmacodynamics of a brinzolamide episcleral sustained release implant in normotensive New Zealand white rabbits, Journal of Drug Delivery Science and Technology, Volume 61,2021,102123, ISSN 1773-2247
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CA II

Alternative Products

CatalogName
263603-01Brinzolamide

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