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Azido-PEG8-amine

CAT: 0804-HY-140216-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140216-01Size:100 mg
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Description
Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG8-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
857891-82-8
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azido-peg8-amine-1.html
Purity
99.87
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Molecular Formula
C18H38N4O8
Molecular Weight
438.52
Precautions
H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol
CAS Number857891-82-8
PubChem CID3309402
IUPAC Name2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Molecular FormulaC18H38N4O8
Molecular Weight438.5
XLogP-1
Topological Polar Surface Area114
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count26
Heavy Atom Count30
Formal Charge0
Complexity376
SMILES
C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI
InChI=1S/C18H38N4O8/c19-1-3-23-5-7-25-9-11-27-13-15-29-17-18-30-16-14-28-12-10-26-8-6-24-4-2-21-22-20/h1-19H2
InChIKey
ZSFGTBJYBWJOLZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol
CAS: 857891-82-8
CID: 3309402
Formula: C18H38N4O8
MW: 438.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.5
XLogP3-1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count11
Rotatable Bond Count26
Exact Mass438.26896418
Monoisotopic Mass438.26896418
Topological Polar Surface Area114 Ų
Heavy Atom Count30
Formal Charge0
Complexity376
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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HY-140815-01Azido-PEG8-hydrazide
HY-138708Azido-PEG8-NHBoc
HY-140454-01Azido-PEG8-acid
HY-130742-01Azido-PEG8-Boc
HY-138391Azido-PEG8-propargyl
HY-132055Azido-PEG8-THP
HY-140214-01Azido-PEG5-amine
HY-130169-01Azido-PEG9-amine

Alternative Products

CatalogName
BIPG1131-01Azido-PEG8-amine
BA2552-1000Azido-PEG8-acid
MBS5800147Azido-PEG8-NHBoc
OR1076629Azido-PEG8-azide
YPC79199Azido-PEG8-Boc
T38582-01Azido-PEG8-propargyl
T17520-01Azido-PEG8-hydrazide
GTR19260911-01Azido-PEG8-THP

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