Products for Research Use Only
RegisterLogin

Lenalidomide-PEG3-iodine

CAT: 0804-HY-130982-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-130982-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[1].
CAS Number
2738934-13-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lenalidomide-peg3-iodine.html
Solubility
10 mM in DMSO
Smiles
O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCI)=C3
Molecular Formula
C19H23IN2O6
Molecular Weight
502.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. Bioorg Med Chem Lett. 2020 Feb 1;30 (3) :126877.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

Related Products

CatalogName
HY-163964Lenalidomide-C3-PEG3-N3
HY-161130Lenalidomide 4'-PEG3-amine (dihydrochloride)
HY-133139-01Lenalidomide-PEG1-azide
HY-A0003-01Lenalidomide
HY-163647Lenalidomide-COCH-PEG2-azido
HY-161134-01Lenalidomide 4'-PEG2-azide
HY-161133Lenalidomide 4'-PEG1-azide
HY-43722-01Lenalidomide-Br
HY-A0003ALenalidomide (hydrochloride)
HY-W039233-01Lenalidomide-F

Alternative Products

CatalogName
T18068-01Lenalidomide-PEG3-iodine
GTR19192323Lenalidomide 4'-PEG3-amine
T89860-01Lenalidomide-C3-PEG3-N3
T208667-01Lenalidomide 4'-PEG3-amine dihydrochloride
19220-95Iodine
FL24864-01Lenalidomide

Popular Products