Lenalidomide-PEG3-iodine

• Target:

  Others|||E3 Ligase Ligand-Linker Conjugate

• Related Pathways:

  Others|||PROTAC

• Bioactivity:

  Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1].

• Smiles:

  O=C (N1) C (CCC1=O) N (C2=O) CC3=C2C=CC (OCCOCCOCCI) =C3

• Molecular Formula:

  C19H23IN2O6

• Molecular Weight:

  502.3

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C