Lenalidomide-PEG3-iodine

• Target :

  Others|||E3 Ligase Ligand-Linker Conjugate

• Related Pathways :

  Others|||PROTAC

• Bioactivity :

  Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1].

• Smiles :

  O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(OCCOCCOCCI)=C3

• Molecular Formula :

  C19H23IN2O6

• Molecular Weight :

  502.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C