TLE1 (Synovial Sarcoma Marker)

TLE1 (Synovial Sarcoma Marker)

• Gene Name: [TLE1]
• NCBI Gene ID: 7088
• Reactivity: Human. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
• Other Gene Names: [TLE1; TLE1; ESG; ESG1; GRG1; ESG1]
• Short Name: [TLE1]
• Other Product Names: [transducin-like enhancer protein 1 isoform 1; Transducin-like enhancer protein 1; transducin-like enhancer protein 1; transducin like enhancer of split 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1]
• NCBI GI Number: 733605268
• NCBI Accession Number: NP_001290032.1
• NCBI GB Accession Number: NM_001303103.1
• Uniprot Accession Number: Q04724