TLE1 (Synovial Sarcoma Marker)

• Gene Name:

  [TLE1]

• NCBI Gene ID:

  7088

• Reactivity:

  Human. Others not known.

• Specificity:

  Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.

• Other Gene Names:

  [TLE1; TLE1; ESG; ESG1; GRG1; ESG1]

• Short Name:

  [TLE1]

• Other Product Names:

  [transducin-like enhancer protein 1 isoform 1; Transducin-like enhancer protein 1; transducin-like enhancer protein 1; transducin like enhancer of split 1; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1]

• NCBI GI Number:

  733605268

• NCBI Accession Number:

  NP_001290032.1

• NCBI GB Accession Number:

  NM_001303103.1

• Uniprot Accession Number:

  Q04724