Lactate

• UNSPSC Description:

  Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lactate.html

• Purity:

  91.61

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CC(O)C(O)=O

• Molecular Weight:

  90.078

• References & Citations:

  [1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13(1):4981. Adv Sci (Weinh). 2024 May 20:e2307216.|Bioact Mater. 2024 Jun 24:40:445-459.|Cancer Immunol Immunother. 2024 Oct 3;73(12):254.|J Ginseng Res. 2023 Dec 27.|Tissue Cell. 2024 Jul 9:89:102468.|Cell Res. 2023 Jul 13.|J Anim Sci Biotechnol. 2024 Jun 11;15(1):86.|J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  50-21-5