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Prexasertib (lactate)

CAT: 0804-HY-18174HSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18174HSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib. Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib lactate shows potent anti-tumor activity[1][2].
CAS Number
2781996-46-9
Product Name Alternative
LY2606368 (lactate)
UNSPSC
12352005
Target
Apoptosis; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prexasertib-lactate.html
Smiles
OC([C@@H](O)C)=O.NCCCOC1=C(C2=CC(NC3=NC=C(C#N)N=C3)=NN2)C(OC)=CC=C1
Molecular Formula
C21H25N7O5
Molecular Weight
455.47
References & Citations
[1]King C, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015 Sep;14 (9) :2004-1|[2]Yin Y, et al. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7 (3) :473-483.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Chk1; Chk2

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CatalogName
T88364-01Prexasertib lactate
T4310L-01Prexasertib lactate hydrate
T4310-01Prexasertib
B2067-5Prexasertib mesylate
MBS3600929-01Prexasertib dihydrochloride
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