Lactic acid (potassium)

• Description :

  Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2]. Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative[3].

• Product Name Alternative :

  DL-Lactic acid (potassium) ; E-270 (potassium)

• UNSPSC :

  12352300

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Bacterial; Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR)

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/lactate-potassium.html

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  OC(C([O-])=O)C.[K+]

• Molecular Formula :

  C3H5KO3

• Molecular Weight :

  128.17

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24.|[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981. |[3]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18 (5) :566-575.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  HCAR1

• CAS Number :

  [996-31-6]