CFM-4

CAT: 0804-HY-103255-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103255-02Size:10 mg

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Description

CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells[1].

CAS Number

331458-02-7

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cfm-4.html

Purity

98.85

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(CC2=CC=CC=C2Cl)C3=C(C=CC=C3)C14SC(C5=CC=CC=C5)=NN4

Molecular Formula

C22H16ClN3OS

Molecular Weight

405.90

References & Citations

[1]Puliyappadamba VT, et al. Antagonists of anaphase-promoting complex (APC) -2-cell cycle and apoptosis regulatory protein (CARP) -1 interaction are novel regulators of cell growth and apoptosis. J Biol Chem. 2011 Nov 4;286 (44) :38000-38017.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one

CAS Number	331458-02-7
PubChem CID	2871439
IUPAC Name	1'-[(2-chlorophenyl)methyl]-5-phenylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one
Molecular Formula	C22H16ClN3OS
Molecular Weight	405.9
XLogP	5.4
Topological Polar Surface Area	70
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	28
Formal Charge	0
Complexity	637

SMILES

C1=CC=C(C=C1)C2=NNC3(S2)C4=CC=CC=C4N(C3=O)CC5=CC=CC=C5Cl

InChI

InChI=1S/C22H16ClN3OS/c23-18-12-6-4-10-16(18)14-26-19-13-7-5-11-17(19)22(21(26)27)25-24-20(28-22)15-8-2-1-3-9-15/h1-13,25H,14H2

InChIKey

PMADITKBVODKSF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 331458-02-7

CID: 2871439

Formula: C22H16ClN3OS

MW: 405.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	405.9
XLogP3	5.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	405.0702610
Monoisotopic Mass	405.0702610
Topological Polar Surface Area	70 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	637
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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B7760-10	CFM 4
abx282374-01	CFM-4
A16379-10	CFM 4 10mg
A16379-500	CFM 4 500mg
A16379-100	CFM 4 100mg
A16379-5	CFM 4 5mg
A16379-50	CFM 4 50mg
A16379-25	CFM 4 25mg
A16379-1	CFM 4 1mg
B6590-5.1	CFM-2

CFM-4

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