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Mouse IL-17A Protein

CAT: 0749-PRP1300-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0749-PRP1300-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-17 (IL-17) is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
Description
IL-17A
Product Name Alternative
Interleukin 17A, CTLA-8, IL17, IL17A
Gene ID
16171
Accession Number
Q62386
Tag
IL-17A
Type
Cytokines and proteins
Applications
No tag
Purity
> 98 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Formula
15.4 kDa
Molecular Weight
15.4 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin : < 0.1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage
Protein Length
The recombinant Mouse IL-17A consists of 137 amino acids and predicts a molecular mass of 15.4 kDa.
Formulation
Lyophilized from sterile 20mM Tris, 50mM NaCl, pH 8.0.
Applications Notes
Mouse
Other Product Names
Interleukin 17A, CTLA-8, IL17, IL17A, IL-17A, IL 17A, IL 17a, il17a, il 17a, il-17a, , Mouse IL-17A Protein, 17A (IL-17A)
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Preparation
E.coli
Accession Number URL
https://www.uniprot.org/uniprotkb/Q62386/entry#sequences
AA Sequence
Amino acid sequence derived from Mouse IL-17A (Ala27-Arg190) (P16612-2) was expressed.

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