Mouse IL-2 Protein

CAT: 0749-PRP1129-01Size: 20 µgDry Ice: NoHazardous: No
CAT#:0749-PRP1129-01Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-2 (IL 2), also known as T cell growth factor, is a member of the cytokine family, including IL-4, IL-7, IL-9, IL-15, and IL-21. Each member of this family has a bundle of four α spirals. IL-2 signals through IL-2 receptors, which are complexes of dendritic subunits called α, β, and γ. γIL-2R is common to the cytokine receptors of all members of the cytokine family. Mature IL2 mice share 56% and 73% of aa sequence identity with human and rat IL2, respectively. Produced by CD4+ Tcells, CD8+ T cells, γ δ T cells, B cells, dendritic cells, and eosinophils, IL-2 plays a vital role in key immune system function, tolerance, and immunity, primarily due to its potent stimulating activity against T cells. Therefore, IL2 may be a key cytokine that naturally suppresses autoimmunity.
Description
Interleukin-2 (IL 2), also known as T cell growth factor, is a member of the cytokine family, including IL-4, IL-7, IL-9, IL-15, and IL-21. Each member of this family has a bundle of four α spirals. IL-2 signals through IL-2 receptors, which are complexes of dendritic subunits called α, β, and γ
Product Name Alternative
IL-2, interleukin-2, T-cell growth factor, TCGF
Gene ID
16183
Accession Number
P04351
Tag
IL-2
Type
Cytokines and proteins
Applications
No tag
Purity
> 95 % as determined by SDS-PAGE
Activity
Measured by its ability to induce proliferation in CTLL-2 cells. The ED50 for this effect is 8.310 ng/mL.
Molecular Weight
17 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin : < 1 EU per 1 μg of the protein as determined by the LAL method
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Mouse IL-2 protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSAor BSA) . Please prevent freeze-thaw cycles
Protein Length
The recombinant Mouse IL-2 (NP_032392.1) (Ala21-Gln169) consists of 149 amino acids and has a predicted molecular mass of 17 kDa
Formulation
Lyophilized from sterile 20mM Tris 300mM NaCl , pH 8.0
Applications Notes
Mouse
Other Product Names
IL-2, interleukin-2, T-cell growth factor, TCGF
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IL-2 protein using the buffer we provided not less than 100µg/ml, which can then be further diluted to other aqueous solutions
Preparation
E. coli
AA Sequence
Amino acid sequence derived from Mouse IL-2 (P04351) .

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