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Mouse IL-6 protein

CAT: 0749-PRP1960-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0749-PRP1960-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that also has an important role in immunity. Mouse IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 in regulating the acute phase response. Mouse IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 has a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, nerve cells differentiation in hepatocytes, and acute phase reactants
Description
Interleukin-6 (IL-6) is a pro-inflammatory cytokine that also has an important role in immunity. Mouse IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 in regulating the acute phase response. Mouse IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 has a wide variety of biological functions: it plays an essential role in the final differentiation of B-cells into Ig-secreting cells, it induces myeloma and plasmacytoma growth, nerve cells differentiation in hepatocytes, and acute phase reactants
Gene ID
16193
Accession Number
P08505
Applications
No tag
Purity
> 99 % as determined by SDS-PAGE
Activity
Measured in a cell proliferation assay using M-NFS60. The ED50 for this effect is typically 1.75 ng/mL.The specific activity of recombinant Mouse IL6 is approximately >5.71 x 105IU/mg.
Molecular Formula
21.9 kDa
Molecular Weight
21.9 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized protein product should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles
Protein Length
The recombinant Mouse IL-6 consists of 187 amino acids and predicts a molecular mass of 21.9 kDa
Formulation
Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 7.4.
Applications Notes
Mouse
Other Product Names
Mouse IL-6 protein、IL-6
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions
Preparation
E.coli
AA Sequence
Amino acid sequence derived from Mouse IL-6 (Phe25-Thr211) (P08505) was expressed.

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