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HDAC10-IN-1

CAT: 0804-HY-144779-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144779-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1].
UNSPSC
12352005
Target
Autophagy; HDAC
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac10-in-1.html
Purity
99.87
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1C=C(C2=C1C=CC=C2)CN3CCC(CC3)/C=C/C(NO)=O
Molecular Formula
C18H23N3O2
Molecular Weight
313.39
References & Citations
[1]Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC10; HDAC6; HDAC8

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