HDAC10-IN-3

• Description:

  HDAC10-IN-3 (Compound 2a) is a potent HDAC10 inhibitor with an IC50s of 0.41, 37, 350 and 4500 nM against HDAC10, HDAC6, HDAC8 and HDAC1. HDAC10-IN-3 exhibits moderate cytotoxicity in KB and SK-OV-3 cells, but does not show significant cytotoxicity against most cancer cell lines. HDAC10-IN-3 can be used for the study of cancers[1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research:

  Cancer

• Smiles:

  O=C(NO)C1=CC=C(CNCC2=CNC3=C2C=CC=C3)C=C1

• Molecular Formula:

  C17H17N3O2

• Molecular Weight:

  295.34

• References & Citations:

  [1]Tarawneh AH, et al. Novel selective indole based histone deacetylase 10 inhibitors as anticancer therapeutics. Sci Rep. 2025 Sep 26;15 (1) :33307.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC10; HDAC6; HDAC8