HDAC10-IN-2

• Description :

  HDAC10-IN-2 (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; HDAC

• Type :

  Reference compound

• Related Pathways :

  Autophagy; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hdac10-in-2.html

• Solubility :

  DMSO : 75 mg/mL (ultrasonic)

• Smiles :

  O=C(NO)/C=C/C1CCN(CC1)CC2=CC=CC3=C2C=CC=C3

• Molecular Formula :

  C19H22N2O2

• Molecular Weight :

  310.39

• References & Citations :

  [1]Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC10; HDAC6; HDAC8