HDAC10-IN-2

• Description:

  HDAC10-IN-2 (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1].

• UNSPSC:

  12352005

• Target:

  Autophagy; HDAC

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac10-in-2.html

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  O=C(NO)/C=C/C1CCN(CC1)CC2=CC=CC3=C2C=CC=C3

• Molecular Formula:

  C19H22N2O2

• Molecular Weight:

  310.39

• References & Citations:

  [1]Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC10; HDAC6; HDAC8